This expansive Handbook guides readers through a multi-layered landscape of the interpretations and uses of transdisciplinary thinking and practices worldwide. It advances understanding of the strengths and limits of transdisciplinary research in the context of societal power relations, institutional structures and social inequalities. Original chapters from 116 scholars and experts in 27 countries create a multi-cultural constellation of conceptual and methodological approaches to transdisciplinary research, teaching, training and community projects, showcasing the diversity and plurality of transdisciplinary contributions. Framed through the core themes of thinking, doing and being, this Handbook thoroughly reviews key topics including philosophies and theories, research and practice, education and training and financial and institutional resources with examples from innovative transdisciplinary global projects. Inclusive in its approach, this Handbook will be an ideal resource for public and private domain professionals wishing to explore collaborative working practices. Scholars looking for a better understanding of transdisciplinarity and how it differs from interdisciplinarity will find the case studies illustrative and informative.